The aim of this work was to prepare hybrid organo-layered materials using intercalation process then evaluated them as a drug release and antibacterial materials. Four kinds of organo-layered materials cetyltrimethylammonium bromide-bentonite (CTA-bent), ampicillin-bentonite (AMP-bent), CTA-magadiite (CTA-mag) and ampicillin-magadiite (AMP-mag) have been prepared and characterized using several techniques. The results showed that the CTA and AMP molecules are incorporated between the interlayer spaces, subsequently leading to an increase of the basal spacing of bentonite and magadiite solids, in which preserving their two-dimensional character. Antibacterial activities of the intercalated layered materials were determined against Gram positive and Gram negative bacteria. The ranking of antibacterial activity of the intercalated materials was as organo-modified bentonite > organo-modified magadiite. In vitro drug release profile in simulated intestinal fluid pH 7.4 at 37 °C was evaluated. A satisfactory percent of cumulative AMP release from AMP-bent was observed. The cumulative drug release from AMP-bent and AMP-mag was 31.13% and 25.24%, respectively. This work highlighted the role of the natural surface of layered materials in the release of a drug by involving surface-drug interaction forces.

中文翻译：

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评价嵌入层状材料作为抗菌和药物输送系统：一项比较研究

这项工作的目的是使用插层工艺制备混合有机层状材料，然后将其作为药物释放和抗菌材料进行评估。已经制备了四种有机层状材料十六烷基三甲基溴化铵-膨润土（CTA-bent）、氨苄青霉素-膨润土（AMP-bent）、CTA-magadiite（CTA-mag）和氨苄青霉素-magadiite（AMP-mag）技术。结果表明，CTA和AMP分子掺入层间空间，随后导致膨润土和magadiite固体的基础间距增加，其中保留了它们的二维特征。测定了嵌入层状材料对革兰氏阳性菌和革兰氏阴性菌的抗菌活性。插层材料的抗菌活性排序为有机改性膨润土>有机改性magadiite。评估了 37 °C 下模拟肠液 pH 7.4 中的体外药物释放曲线。观察到 AMP 弯曲的累积 AMP 释放百分比令人满意。AMP-bent 和 AMP-mag 的累积药物释放分别为 31.13% 和 25.24%。这项工作通过涉及表面-药物相互作用力，突出了层状材料的天然表面在药物释放中的作用。