Carrying different aspects of emotional and motivational signals, glutamatergic synaptic projections from multiple limbic and paralimbic brain regions converge to the nucleus accumbens (NAc), in which these arousing signals are processed and prioritized for behavioral output. In animal models of drug addiction, some key drug-induced alterations at NAc glutamatergic synapses underlie important cellular and circuit mechanisms that promote subsequent drug taking, seeking, and relapse. With the focus of cocaine, we review changes at NAc glutamatergic synapses that occur after different drug procedures and abstinence durations, and the behavioral impact of these changes.

中文翻译：

---

精神兴奋剂诱导的伏隔核谷氨酸能传递适应。

携带情绪和动机信号的不同方面，来自多个边缘和上肢大脑区域的谷氨酸能突触投射会聚到伏隔核（NAc），在这些伏隔核中会处理这些激起的信号并为行为输出确定优先级。在药物成瘾的动物模型中，NAc谷氨酸能突触的一些关键药物诱导的改变是重要的细胞和回路机制的基础，这些机制促进了随后的药物吸收，寻找和复发。我们以可卡因为重点，回顾了不同药物程序和禁欲时间后发生的NAc谷氨酸能突触的变化，以及这些变化的行为影响。