Ninety percent of childhood renal tumors are Wilms tumors (nephroblastoma). While the Children’s Oncology Group (COG) recommends primary surgery, the International Society of Paediatric Oncology (SIOP) recommends neoadjuvant chemotherapy, which can be initiated without histological confirmation if the presentation is typical for Wilms tumor. This review article describes the clinical, biological and radiologic criteria used by the SIOP community to consider diagnostic biopsy, i.e. when the renal origin is doubtful, when a pseudotumor is suspected or when a non-Wilms histology may be anticipated.

中文翻译：

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从Wilms到肾肿瘤：哪些需要活检？

儿童期肾肿瘤的百分之九十是威尔姆斯肿瘤（成纤维细胞瘤）。儿童肿瘤学小组（COG）建议进行初次手术，而国际儿科肿瘤学会（SIOP）则建议新辅助化疗，如果该报告是典型的Wilms肿瘤，则无需组织学确认即可开始。这篇综述文章描述了SIOP社区用于考虑诊断性活检的临床，生物学和放射学标准，即当怀疑肾脏来源，怀疑有假瘤或预期出现非Wilms组织学时。