Abstract
Ninety percent of childhood renal tumors are Wilms tumors (nephroblastoma). While the Children’s Oncology Group (COG) recommends primary surgery, the International Society of Paediatric Oncology (SIOP) recommends neoadjuvant chemotherapy, which can be initiated without histological confirmation if the presentation is typical for Wilms tumor. This review article describes the clinical, biological and radiologic criteria used by the SIOP community to consider diagnostic biopsy, i.e. when the renal origin is doubtful, when a pseudotumor is suspected or when a non-Wilms histology may be anticipated.
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de la Monneraye Y, Michon J, Pacquement H et al (2019) Indications and results of diagnostic biopsy in pediatric renal tumors: a retrospective analysis of 317 patients with critical review of SIOP guidelines. Pediatr Blood Cancer 66:e27641
Lemerle J, Voute PA, Tournade MF et al (1983) Effectiveness of preoperative chemotherapy in Wilms' tumor: results of an International Society of Paediatric Oncology (SIOP) clinical trial. J Clin Oncol 1:604–609
van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K et al (2017) Position paper: rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol 14:743–752
Irtan S, Jitlal M, Bate J et al (2015) Risk factors for local recurrence in Wilms tumour and the potential influence of biopsy - the United Kingdom experience. Eur J Cancer 51:225–232
Fernandez CV, Mullen EA, Chi YY et al (2018) Outcome and prognostic factors in stage III favorable-histology Wilms tumor: a report from the Children’s Oncology Group study AREN0532. J Clin Oncol 36:254–261
D'Angio GJ (2007) The National Wilms Tumor Study: a 40 year perspective. Lifetime Data Anal 13:463–470
Dickson PV, Sims TL, Streck CJ et al (2008) Avoiding misdiagnosing neuroblastoma as Wilms tumor. J Pediatr Surg 43:1159–1163
Gow KW, Barnhart DC, Hamilton TE et al (2013) Primary nephrectomy and intraoperative tumor spill: report from the Children’s Oncology Group (COG) renal tumors committee. J Pediatr Surg 48:34–38
Fukuzawa H, Shiima Y, Mishima Y et al (2017) Predictive factor for intraoperative tumor rupture of Wilms tumor. Pediatr Surg Int 33:91–95
Jackson TJ, Williams RD, Brok J et al (2019) The diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: report of the UK experience in the SIOP UK WT 2001 trial. Pediatr Blood Cancer 66:e27627
van den Heuvel-Eibrink MM, van Tinteren H, Rehorst H et al (2011) Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the SIOP renal tumour study group. Pediatr Blood Cancer 56:733–737
Brisse H, de La Monneraye Y, Schleiermacher G (2019) Reply to comment on: the diagnostic accuracy and clinical utility of pediatric renal tumor biopsy: report of the UK experience in the SIOP UK WT2001 trial. Pediatr Blood Cancer 66:e27828
Underwood JJ, Quadri RS, Kalva SP et al (2020) Liquid biopsy for Cancer: review and implications for the radiologist. Radiology 294:5–17
Jimenez I, Chicard M, Colmet-Daage L et al (2019) Circulating tumor DNA analysis enables molecular characterization of pediatric renal tumors at diagnosis. Int J Cancer 144:68–79
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Brisse, H.J., de la Monneraye, Y., Cardoen, L. et al. From Wilms to kidney tumors: which ones require a biopsy?. Pediatr Radiol 50, 1049–1051 (2020). https://doi.org/10.1007/s00247-020-04660-x
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DOI: https://doi.org/10.1007/s00247-020-04660-x