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Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes.
Archives of Virology ( IF 2.5 ) Pub Date : 2020-04-04 , DOI: 10.1007/s00705-020-04619-1
Aizhan S Turmagambetova 1 , Madina S Alexyuk 1 , Andrey P Bogoyavlenskiy 1 , Pavel G Alexyuk 1 , Irina A Zaitseva 1 , Elmira S Omirtaeva 1 , Nadezhda S Sokolova 1 , Vladimir E Berezin 1
Affiliation  

The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFNγ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.

中文翻译:

纳米胶囊佐剂Sapomax对某些免疫反应基因表达的影响。

纳米胶囊佐剂Sapomax的使用增加了对流感病毒(即属于RLR和TLR家族的那些病毒)的主要识别的先天免疫基因(H2Q10,Ddx58,Tyk2,Tlr3,Tlr7和TNF)的表达;与刺激I型和III型IFN和促炎细胞因子产生有关的基因;Th1和Th2细胞免疫基因(Ccr4,Ccr5,IFNγ,IL-2,IL-4和IL-10)负责触发细胞中的调节性免疫机制。植物来源的纳米囊化佐剂Sapomax的高免疫活性可用于增强疫苗效力。
更新日期:2020-04-04
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