Abstract
The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFNγ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.
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References
Son YO, Kook SH, Lee JC (2017) Glycoproteins and polysaccharides are the main class of active constituents required for lymphocyte stimulation and antigen-specific immune response induction by traditional medicinal herbal plants. J Med Food. https://doi.org/10.1089/jmf.2017.3943
Wei W, Feng L, Bao WR et al (2016) Structure characterization and immunomodulating effects of polysaccharides isolated from Dendrobium officinale. J Agric Food Chem 64:881–889. https://doi.org/10.1021/acs.jafc.5b05180
Brunner R, Jensen-Jarolim E, Pali-Schöll I (2010) The ABC of clinical and experimental adjuvants—a brief overview. Immunol Lett 128(1):29–35. https://doi.org/10.1016/j.imlet.2009.10.005
Meshcheryakova E, Makarov E, Philpott D et al (2007) Evidence for correlation between the intensities of adjuvant effects and NOD2 activation by monomeric, dimeric and lipophylic derivatives of N-acetylglucosaminyl-N-acetylmuramyl peptides. Vaccine. 25:4515–4520. https://doi.org/10.1016/j.vaccine.2007.04.006
Glenny AT, Pope CG, Waddington H, Wallace U (1926) Immunological notes. J Pathol Bacteriol 29:31–40. https://doi.org/10.1002/path.1700290106
Jones FG (1936) The antitoxic titer of human subjects following immunization with tetanus toxoid and tetanus alum precipitated toxoid. J Immunol 30:115–125
Goullé JP, Grangeot-Keros L (2019) Aluminum and vaccines: current state of knowledge. Med Mal Infect. https://doi.org/10.1016/j.medmal.2019.09.012
Kensil CR, Patel U, Lennick M, Marciani D (1991) Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J Immunol 146:431–437
Hu KF, Ekstrom J, Merza M et al (1999) Induction of antibody responses in the common mucosal immune system by respiratory syncitial virus immunostimulating complex. Med Microbiol Immunol 187:191–198. https://doi.org/10.1007/s004300050092
Shah RR, Hassett KJ, Brito LA (2017) Overview of vaccine adjuvants: introduction, history, and current status. Methods Mol Biol 1494:1–13. https://doi.org/10.1007/978-1-4939-6445-1_1
Turmagambetova AS, Alexyuk PG, Bogoyavlenskiy AP et al (2017) Adjuvant activity of saponins from Kazakhstani plants on the immune responses to subunit influenza vaccine. Arch Virol 162(12):3817–3826. https://doi.org/10.1007/s00705-017-3560-5
Berezin VE, Zaides VM, Isaeva ES et al (1988) Controlled organization of multimolecular complexes of enveloped virus glycoproteins: study of immunogenicity. Vaccine 6:450–456. https://doi.org/10.1016/0264-410X(88)90148-X
Klimov A, Balish A, Veguilla V et al (2012) Influenza virus titration, antigenic characterization, and serological methods for antibody detection. Methods Mol Biol 865:25–51. https://doi.org/10.1007/978-1-61779-621-0_3
Carlsson N, Borde A, Wölfel S et al (2011) Quantification of protein concentration by the Bradford method in the presence of pharmaceutical polymers. Anal Biochem 411(1):116–121. https://doi.org/10.1016/j.ab.2010.12.026
He P, Zou Y, Hu Z (2015) Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother 11:477–488. https://doi.org/10.1080/21645515.2014.1004026
Rehwinkel J, Tan CP, Goubau D et al (2010) RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140:397–408. https://doi.org/10.1016/j.cell.2010.01.020
Kim YM, Brinkmann MM, Paquet ME, Ploegh HL (2008) UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452:234–238. https://doi.org/10.1038/nature06726
Karjalainen A, Shoebridge S, Krunic M et al (2020) TYK2 in tumor immunosurveillance. Cancers 12(1):E150. https://doi.org/10.3390/cancers12010150
Abouelasrar Salama S, Lavie M, De Buck M et al (2019) Cytokines and serum amyloid A in the pathogenesis of hepatitis C virus infection. Cytokine Growth Factor Rev 50:29–42. https://doi.org/10.1016/j.cytogfr.2019.10.006
Ferreiro I, Joaquin M, Islam A et al (2010) Whole genome analysis of p38 SAPK-mediated gene expression upon stress. BMC Genom 11:144. https://doi.org/10.1186/1471-2164-11-144)
Acknowledgements
This work was supported by the Ministry of Education and Science of the Republic of Kazakhstan (Grant numbers: BR05236330, AP05130957).
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Turmagambetova, A.S., Alexyuk, M.S., Bogoyavlenskiy, A.P. et al. Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes. Arch Virol 165, 1445–1451 (2020). https://doi.org/10.1007/s00705-020-04619-1
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DOI: https://doi.org/10.1007/s00705-020-04619-1