Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydrazone exhibited pronounced specific activity in a Hoechst experiment against lung carcinoma (A-549) and colorectal adenocarcinoma cell lines (DLD-1).

中文翻译：

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表雄酮腙的合成及细胞毒性

分别由 3β-羟基-和 3β-(1-金刚酸)-5α-androstan-17- 合成两个系列的腙，以研究构效关系。细胞毒性研究表明，5α-androstan-3β-ol-17-one 间硝基苯甲酰腙在针对肺癌 (A-549) 和结直肠腺癌细胞系 (DLD-1) 的 Hoechst 实验中表现出明显的比活性。