Skip to main content
SpringerLink
Log in

Synthesis and Cytotoxicity of Epiandrosterone Hydrazones

  • Published:
Chemistry of Natural Compounds Aims and scope

Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydrazone exhibited pronounced specific activity in a Hoechst experiment against lung carcinoma (A-549) and colorectal adenocarcinoma cell lines (DLD-1).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Chen, H. Wu, A. Li, J. Pei, and L. Zhao, Res. Chem. Intermed., 44 (11), 7029 (2018).

    Article  CAS  Google Scholar 

  2. C. Gan, J. Cui, S. Su, Q. Lin, L. Jia, L. Fan, and Y. Huang, Steroids, 87, 99 (2014).

    Article  CAS  Google Scholar 

  3. J. Cui, L. Liu, D. Zhao, C. Gan, X. Huang, Q. Xiao, B. Qi, L. Yang, and Y. Huang, Steroids, 95, 32 (2015).

    Article  CAS  Google Scholar 

  4. C. Gan, L. Liu, J. Cui, Z. Liu, H. Shi, Q. Lin, H. Sheng, C. Yang, and Y. Huang, Med. Chem., 13 (4), 375 (2017).

    Article  CAS  Google Scholar 

  5. Sh. Ke, Y. Wei, L. Shi, Q. Yang, and Z. Yang, Anti-Cancer Agents Med. Chem., 13 (8), 1280 (2013).

    Article  CAS  Google Scholar 

  6. A. H. Banday, B. P. Mir, I. H. Lone, K. A. Suri, and H. M. S. Kumar, Steroids, 75, 805 (2010).

    Article  CAS  Google Scholar 

  7. V. Yu. Kovtun and V. M. Plakhotnik, Khim.-farm. Zh., 21 (8), 931 (1987).

  8. R. T. Rapala, R. J. Kraay, and K. Gerzon, J. Med. Chem., 8 (5), 580 (1965).

    Article  CAS  Google Scholar 

  9. N. Sh. Nadaraia, L. Sh. Amiranashvili, M. Merlani, M. L. Kakhabrishvili, N. N. Barbakadze, A. Geronikaki, A. Petrou, V. Poroikov, A. Ciric, J. Glamoclija, and M. Sokovic, Steroids, 144, 52 (2019).

    Article  CAS  Google Scholar 

  10. N. Sh. Nadaraia, M. L. Kakhabrishvili, N. N. Barbakadze, V. D. Mshvildadze, B. Sylla, J. Legault, and A. Pichette, Chem. Nat. Compd., 54, 926 (2018).

    Article  CAS  Google Scholar 

  11. N. Sh. Nadaraia, N. N. Barbakadze, M. L. Kakhabrishvili, B. Sylla, A. Pichette, and U. S. Makhmudov, Chem. Nat. Compd., 54, 310 (2018).

    Article  CAS  Google Scholar 

  12. M. I. Sikharulidze, N. Sh. Nadaraia, M. L. Kakhabrishvili, and M. O. Labartkava, Chem. Nat. Compd., 43, 753 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, 0159, Tbilisi, Georgia

    N. Sh. Nadaraia, N. N. Barbakadze & V. D. Mshvildadze

  2. LASEVE, Universite Quebec a Chicoutimi, Chicoutimi, QC, G7H 2B1, Canada

    V. D. Mshvildadze, B. Sylla, J. Legault & A. Pichette

Authors
  1. N. Sh. Nadaraia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. N. Barbakadze
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. D. Mshvildadze
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Sylla
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Legault
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Pichette
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to N. Sh. Nadaraia or A. Pichette.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2020, pp. 239–241.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nadaraia, N.S., Barbakadze, N.N., Mshvildadze, V.D. et al. Synthesis and Cytotoxicity of Epiandrosterone Hydrazones. Chem Nat Compd 56, 274–277 (2020). https://doi.org/10.1007/s10600-020-03005-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-020-03005-2

Keywords

Search

Navigation