The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases.,Cellular & Molecular Immunology

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The pathogenic role of innate lymphoid cells in autoimmune-related and inflammatory skin diseases.
Cellular & Molecular Immunology ( IF 21.8 ) Pub Date : 2020-03-19 , DOI: 10.1038/s41423-020-0399-6
Suqing Zhou ₁ , Qianwen Li ₁ , Haijing Wu ₁ , Qianjin Lu ₁

Affiliation

Innate lymphoid cells (ILCs), as an important component of the innate immune system, arise from a common lymphoid progenitor and are located in mucosal barriers and various tissues, including the intestine, skin, lung, and adipose tissue. ILCs are heterogeneous subsets of lymphocytes that have emerging roles in orchestrating immune response and contribute to maintain metabolic homeostasis and regulate tissue inflammation. Currently, more details about the pathways for the development and differentiation of ILCs have largely been elucidated, and cytokine secretion and downstream immune cell responses in disease pathogenesis have been reported. Recent research has identified that several distinct subsets of ILCs at skin barriers are involved in the complex regulatory network in local immunity, potentiating adaptive immunity and the inflammatory response. Of note, additional studies that assess the effects of ILCs are required to better define how ILCs regulate their development and functions and how they interact with other immune cells in autoimmune-related and inflammatory skin disorders. In this review, we will distill recent research progress in ILC biology, abnormal functions and potential pathogenic mechanisms in autoimmune-related skin diseases, including systemic lupus erythematosus (SLE), scleroderma and inflammatory diseases, as well as psoriasis and atopic dermatitis (AD), thereby giving a comprehensive review of the diversity and plasticity of ILCs and their unique functions in disease conditions with the aim to provide new insights into molecular diagnosis and suggest potential value in immunotherapy.

中文翻译：

先天淋巴细胞在自身免疫相关和炎症性皮肤病中的致病作用。

先天性淋巴细胞（ILC）作为先天免疫系统的重要组成部分，起源于共同的淋巴祖细胞，位于粘膜屏障和各种组织中，包括肠道、皮肤、肺和脂肪组织。ILC 是淋巴细胞的异质子集，在协调免疫反应中发挥着新兴作用，有助于维持代谢稳态和调节组织炎症。目前，关于ILC的发育和分化途径的更多细节已基本阐明，并且疾病发病机制中的细胞因子分泌和下游免疫细胞反应也已被报道。最近的研究发现，皮肤屏障处的 ILC 的几个不同亚群参与了局部免疫的复杂调节网络，增强了适应性免疫和炎症反应。值得注意的是，需要进行更多研究来评估 ILC 的作用，以更好地确定 ILC 如何调节其发育和功能，以及它们如何与自身免疫相关和炎症性皮肤病中的其他免疫细胞相互作用。在这篇综述中，我们将总结自身免疫相关皮肤病（包括系统性红斑狼疮（SLE）、硬皮病和炎症性疾病，以及银屑病和特应性皮炎（AD））中ILC生物学、异常功能和潜在致病机制的最新研究进展。从而对 ILC 的多样性和可塑性及其在疾病条件下的独特功能进行全面综述，旨在为分子诊断提供新的见解并提示其在免疫治疗中的潜在价值。

更新日期：2020-04-24

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