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Peculiarities of Cardiohemodynamics and its Autonomic Regulation in Elderly People
Journal of Evolutionary Biochemistry and Physiology ( IF 0.6 ) Pub Date : 2019-11-01 , DOI: 10.1134/s0022093019060061
V. P. Nesterov , A. I. Burdygin , S. V. Nesterov , K. B. Ivanov , S. M. Korotkov , K. V. Sobol , I. V. Shemarova

The study was aimed to the experimental verification of the authors’ hypothesis that in elderly people an endogenous functional mechanism develops during late ontogeny to protect muscle effectors of the cardiovascular system (CVS) against negative effects of excessive activity of the sympathetic nervous system by partial replacement of its neurotransmitter norepinephrine with humoral catecholamines. Experiments were carried out using our original method of arterial piezopulsometry which allows evaluation of cardiohemodynamic parameters, as well as the spectral power of oscillations of VmaxPP and TNN parameters of arterial blood pressure pulse waves caused by regulatory effects of the autonomic nervous and endocrine systems. Such a replacement is assumed to be crucial for raising the metabolic tolerance of the CVS in elderly people to an age-related increase in oxygen deficiency, as well as for reducing the incidence of tachyarrhythmia, stenocardia and other cardiac pathological conditions under the influence of psychoemotional and physical stressors.

中文翻译:

老年人心血流动力学特点及其自主调节

该研究旨在通过实验验证作者的假设,即老年人在个体发育晚期发展出一种内源性功能机制,以保护心血管系统 (CVS) 的肌肉效应器免受部分替代交感神经系统过度活动的负面影响。其神经递质去甲肾上腺素与体液儿茶酚胺。实验是使用我们原始的动脉压脉搏计方法进行的,该方法可以评估心脏血流动力学参数,以及由自主神经和内分泌系统的调节作用引起的动脉血压脉搏波的 VmaxPP 和 TNN 参数的振荡频谱功率。
更新日期:2019-11-01
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