Abstract
The study was aimed to the experimental verification of the authors’ hypothesis that in elderly people an endogenous functional mechanism develops during late ontogeny to protect muscle effectors of the cardiovascular system (CVS) against negative effects of excessive activity of the sympathetic nervous system by partial replacement of its neurotransmitter norepinephrine with humoral catecholamines. Experiments were carried out using our original method of arterial piezopulsometry which allows evaluation of cardiohemodynamic parameters, as well as the spectral power of oscillations of VmaxPP and TNN parameters of arterial blood pressure pulse waves caused by regulatory effects of the autonomic nervous and endocrine systems. Such a replacement is assumed to be crucial for raising the metabolic tolerance of the CVS in elderly people to an age-related increase in oxygen deficiency, as well as for reducing the incidence of tachyarrhythmia, stenocardia and other cardiac pathological conditions under the influence of psychoemotional and physical stressors.
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Acknowledgments
The authors are grateful to manufacturers of the Piezopulsar (VASA-PULSE, St. Petersburg) who let us use a test sample of the innovative device APP 2
Funding
This work was implemented within a FASO Russia’s state assignment; theme no. AAAA-A18-118012290142-9.
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All procedures that involved human subject as research objects met international and domestic ethical standards and principles of the Declaration of Helsinki (1964), as well as its later revisions. Although all recordings were carried out using noninvasive sensors put onto pulsatile bodily areas and hence could not do harm to the subjects, all the latter gave their written informed consent to be involved in the experiments.
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Russian Text © The Author(s), 2019, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2019, Vol. 55, No. 6, pp. 433–442.
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Nesterov, V.P., Burdygin, A.I., Nesterov, S.V. et al. Peculiarities of Cardiohemodynamics and its Autonomic Regulation in Elderly People. J Evol Biochem Phys 55, 483–492 (2019). https://doi.org/10.1134/S0022093019060061
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DOI: https://doi.org/10.1134/S0022093019060061