Abstract

Recombinant analogue of the sea anemone Heteractismagnifica peptide was obtained, and the kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than the medical drug acarbose (Precose^TM or Glucobay^TM). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.

中文翻译：

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Magnificamide是一种新型的有效哺乳动物α-淀粉酶抑制剂。

摘要

海葵的重组类似物Heteractis magnifica得到的肽，并测定其与哺乳动物α淀粉酶相互作用的动力学参数。Magnificamide抑制α-淀粉酶的作用明显强于药物阿卡波糖（Precose ^TM或Glucobay ^TM）。认为Magnificamide可作为预防和治疗代谢紊乱和2型糖尿病的药物。