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Magnificamide Is a New Effective Mammalian α-Amylase Inhibitor.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-03-04 , DOI: 10.1134/s1607672919060097 O V Sintsova 1 , E V Leychenko 1 , I N Gladkikh 1 , A P Kalinovskii 1, 2 , M M Monastyrnaya 1 , E P Kozlovskaya 1
中文翻译:
Magnificamide是一种新型的有效哺乳动物α-淀粉酶抑制剂。
更新日期:2020-03-04
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-03-04 , DOI: 10.1134/s1607672919060097 O V Sintsova 1 , E V Leychenko 1 , I N Gladkikh 1 , A P Kalinovskii 1, 2 , M M Monastyrnaya 1 , E P Kozlovskaya 1
Affiliation
Abstract
Recombinant analogue of the sea anemone Heteractismagnifica peptide was obtained, and the kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than the medical drug acarbose (PrecoseTM or GlucobayTM). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.中文翻译:
Magnificamide是一种新型的有效哺乳动物α-淀粉酶抑制剂。