In skeletal muscle fibers, ubiquitous membrane trafficking pathways responsible for transporting newly synthesized proteins, recycling cell surface receptors, and organizing membrane compartmentation have adapted to the high needs of an extremely specialized cell under constant mechanical stress. Membrane remodeling proteins involved in ubiquitous mechanisms such as clathrin-mediated endocytosis, caveolae formation, and membrane fusion have evolved to produce new pathways with sometimes completely different functions such as adhesion and mechanoprotection. In this review, I discuss recent advances in understanding the specialized features of skeletal muscle clathrin-coated plaques, caveolae, and dysferlin-mediated membrane repair. A special emphasis is given on recent findings suggesting that membrane trafficking pathways have evolved to participate into the mechanisms responsible for sarcolemma resistance to mechanical stress and discuss how defects in these pathways result in muscle disease.

中文翻译：

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膜运输蛋白在响应肌膜应力方面的非常规作用。

在骨骼肌纤维中，负责运输新合成蛋白质，回收细胞表面受体和组织膜区隔的无处不在的膜运输途径已经适应了在恒定机械应力下对高度专业化细胞的高需求。与网格蛋白介导的内吞作用，小窝形成和膜融合等普遍存在的机制有关的膜重塑蛋白已经进化为产生新的途径，有时具有完全不同的功能，如粘附和机械保护。在这篇综述中，我将讨论在了解骨骼肌网格蛋白涂层的斑块，小窝和dysferlin介导的膜修复的特殊功能方面的最新进展。