Tumour-infiltrating myeloid cells (TIMCs) are critical regulators of cancer growth. The different phenotypes, functions and therapeutic effects of these phagocytes have, however, been difficult to study. With the advent of single-cell-based technologies, a new 'worldview' is emerging: the classification of TIMCs into subtypes that are conserved across patients and across species. As the landscape of TIMCs is beginning to be understood, it opens up questions about the function of each TIMC subtype and its drugability. In this Perspective, we outline the current map of TIMC populations in cancer and their known and presumed functions, and discuss their therapeutic implications and the biological research questions that they give rise to. The answers should be particularly relevant for bioengineers, materials scientists and the chemical and pharmaceutical communities developing the next generation of cancer therapies.

中文翻译：

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影响癌症治疗的炎症细胞的不断扩大。

肿瘤浸润性骨髓细胞 (TIMC) 是癌症生长的关键调节剂。然而，这些吞噬细胞的不同表型、功能和治疗效果一直难以研究。随着基于单细胞的技术的出现，一种新的“世界观”正在出现：将 TIMC 分类为跨患者和跨物种保守的亚型。随着人们开始了解 TIMCs 的情况，它提出了关于每个 TIMC 亚型的功能及其可药性的问题。在这个视角中，我们概述了癌症中 TIMC 人群的当前地图及其已知和假定的功能，并讨论了它们的治疗意义和它们引起的生物学研究问题。答案应该与生物工程师特别相关，