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LRR-ning the Rules: Synapse Organization in the Primary Rod Pathway.
Neuron ( IF 16.2 ) Pub Date : 2020-03-18 , DOI: 10.1016/j.neuron.2020.02.027
Yi-Rong Peng 1 , Alapakkam P Sampath 1
Affiliation  

In this issue of Neuron, Sinha et al. (2020) demonstrate that synaptic organization at rod bipolar cell terminals is regulated by a leucine-rich repeat protein, LRRTM4. LRRTM4 is expressed specifically by rod bipolar cells; eliminating it in mouse retina perturbs the organization of synaptic ribbons and impairs the function of inhibitory synapses.



中文翻译:

对规则进行LRR:主要杆通路中的突触组织。

在本期Neuron中,Sinha等人。(2020)证明杆双极细胞末端的突触组织受富含亮氨酸的重复蛋白LRRTM4调控。LRRTM4由杆状双极细胞特异性表达。在小鼠视网膜中消除它会扰动突触带的组织,并削弱抑制性突触的功能。

更新日期:2020-03-19
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