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A macrophage-derived adipokine supports skeletal muscle regeneration.
Nature Metabolism ( IF 20.8 ) Pub Date : 2020-03-16 , DOI: 10.1038/s42255-020-0186-9
Bénédicte Chazaud 1
Affiliation  

Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

中文翻译:

巨噬细胞来源的脂肪因子支持骨骼肌再生。

巨噬细胞是损伤后骨骼肌再生所必需的。一项新的研究表明,促炎性巨噬细胞产生类铁蛋白,从而促进肌肉干细胞通过Stat3–IGF1轴扩展,然后改变其炎性特征,使其恢复稳态。
更新日期:2020-03-16
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