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MUSCLE REGENERATION

A macrophage-derived adipokine supports skeletal muscle regeneration

Nature Metabolism volume 2, pages 213–214 (2020)Cite this article

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Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

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Fig. 1: Macrophage-derived Metrnl promotes skeletal muscle regeneration.

References

  1. Baht, G. S. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0184-y (2020).

  2. Dort, J., Fabre, P., Molina, T. & Dumont, N. A. Stem Cells Int. 2019, 4761427 (2019).

    Article  Google Scholar 

  3. Tonkin, J. et al. Mol. Ther. 23, 1189–1200 (2015).

    Article  CAS  Google Scholar 

  4. Lu, H. et al. FASEB J. 25, 358–369 (2011).

    Article  CAS  Google Scholar 

  5. Du, H. et al. Nat. Commun. 8, 669 (2017).

    Article  Google Scholar 

  6. McArthur, S. et al. J. Clin. Invest. https://doi.org/10.1172/JCI124635 (2020).

  7. Giannakis, N. et al. Nat. Immunol. 20, 626–636 (2019).

    Article  CAS  Google Scholar 

  8. Rao, R. R. et al. Cell 157, 1279–1291 (2014).

    Article  CAS  Google Scholar 

  9. Pedersen, B. K. & Febbraio, M. A. Physiol. Rev. 88, 1379–1406 (2008).

    Article  CAS  Google Scholar 

  10. Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M. & Muñoz-Cánoves, P. Cell Metab. 7, 33–44 (2008).

    Article  CAS  Google Scholar 

  11. Zhang, C. et al. J. Biol. Chem. 288, 1489–1499 (2013).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U1217, Université Lyon, Villeurbanne, France

    Bénédicte Chazaud

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  1. Bénédicte Chazaud
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Correspondence to Bénédicte Chazaud.

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Chazaud, B. A macrophage-derived adipokine supports skeletal muscle regeneration. Nat Metab 2, 213–214 (2020). https://doi.org/10.1038/s42255-020-0186-9

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