Abstract

The essential and naturally occurring transition metal manganese (Mn) is present in the soil, water, air, and various foods. Manganese can accumulate in the brain if the Mn intake or exposure is excessive and this can result in neurotoxic effects. Manganese is important for the proper activation of different metabolic and antioxidant enzymes. There are numerous Mn importers and exporters. However, the exact transport mechanism for Mn is not fully understood. On the other hand, iron (Fe) is another well-known essential metal, which has redox activity in addition to chemical characteristics resembling those of Mn. Existing data show that interactions occur between Fe and Mn due to certain similarities regarding their mechanisms of the absorption and the transport. It has been disclosed that Mn-specific transporters, together with Fe transporters, regulate the Mn distribution in the brain and other peripheral tissues. In PC12 cells, a significant increase of transferrin receptor (TfR) mRNA expression was linked to Mn exposure and accompanied by elevated Fe uptake. In both humans and animals, there is a strong relationship between Fe and Mn metabolism. In the present review, special attention is paid to the interaction between Mn and Fe. In particular, Fe and Mn distribution, as well as the potential molecular mechanisms of Mn-induced neurotoxicity in cases of Fe deficiency, are discussed.

中文翻译：

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铁和锰之间的相互作用具有神经毒性。

摘要

土壤，水，空气和各种食物中都存在必需的天然存在的过渡金属锰（Mn）。如果锰摄入或暴露过多，锰会在大脑中蓄积，这会导致神经毒性。锰对于正确激活不同代谢和抗氧化酶很重要。锰的进口商和出口商众多。但是，尚未完全了解Mn的确切传输机理。另一方面，铁（Fe）是另一种众所周知的必需金属，除了具有类似于Mn的化学特性之外，还具有氧化还原活性。现有数据表明，由于铁和锰的吸收和传输机理存在某些相似性，因此它们之间会发生相互作用。已经公开了Mn特异性转运蛋白与Fe转运蛋白一起，调节大脑和其他周围组织中的锰分布。在PC12细胞中，转铁蛋白受体（TfR）mRNA表达的显着增加与Mn暴露有关，并伴有Fe摄取增加。在人类和动物中，铁和锰的代谢之间都有很强的关系。在本综述中，应特别注意Mn和Fe之间的相互作用。特别讨论了铁和锰的分布，以及在铁缺乏时锰诱发的神经毒性的潜在分子机制。在本综述中，要特别注意锰和铁之间的相互作用。特别讨论了铁和锰的分布，以及在铁缺乏时锰诱发的神经毒性的潜在分子机制。在本综述中，应特别注意Mn和Fe之间的相互作用。特别讨论了铁和锰的分布，以及在铁缺乏时锰诱发的神经毒性的潜在分子机制。