MDR uropathogens lead to high-level morbidity and mortality and pose a tremendous threat towards treatment failure and survival of UTI patients. This study was conducted to evaluate the demographic characteristics, antibiogram, and resistance pattern of Escherichia coli against antibiotics—a retrospective study at Nishtar Medical Hospital in Multan, from June 2016 to July 2017. A total of 150 clinical samples were collected and biochemically characterized by Berge’s manual, and antimicrobial susceptibility testing was performed by using the Kirby–Bauer disc diffusion method and the results were interpreted according to Clinical and Laboratory Standards Institute standards. Data was analyzed by the XL-stat software. Results indicate that UTI was more prevalent in rural areas such as Alipur (28.6%) and Jalalpur (18%) and less common in urban areas like Muzaffargarh (2.66) and Multan (2%). A total of 150 patients were examined, of which 88 were females and 62 males in which more frequently found pathogens were E. coli (33%) and others Klebsiella pneumonia (18%), Proteus (10%), Staphylococcus saprophyticus (8.66%), Staphylococcus aureus (7.33%), Pseudomonas aeruginosa (6.66%), Enterobacter (6%), Candida (5.33%), and Citrobacter (4.66%). The antimicrobial susceptibility testing was carried out against E. coli strains that showed the highest overall resistance patterns of imipenem (IMI), Cip, Aug, Cfm, and CN, which were 80%, 72%, 68%, 60%, and 52%, respectively. MDR E. coli strains showed the highest resistance pattern towards IMI which put through alarming situation in Pakistan. Significant results showed that TZP, AK, and F were found sensitive in vitro against E. coli isolates of UTIs. Prevalence of MDR uropathogens near around Multan has been first time documented in this study with respect to possible risk factors associated with UTI. These alarming signs of MDR E. coli have been rarely addressed and warrant attention on urgent basis.

中文翻译：

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MDR E的患病率和抗菌谱。从UTI患者中分离出的大肠杆菌菌株—在木尔坦尼什塔尔医学医院进行的1年回顾性研究

MDR尿路致病菌导致高水平的发病率和死亡率，并对UTI患者的治疗失败和生存构成巨大威胁。进行这项研究以评估大肠杆菌的人口统计学特征，抗菌素和耐药性抗生素的抗逆性研究– 2016年6月至2017年7月在木尔坦Nishtar医院进行的回顾性研究。共收集了150份临床样品并通过Berge手册进行了生化鉴定，并使用Kirby–Bauer椎间盘扩散法进行了药敏试验并根据临床和实验室标准协会的标准对结果进行了解释。通过XL-stat软件分析数据。结果表明，尿路感染在阿里布尔（28.6％）和贾拉普尔（18％）等农村地区更为普遍，而在穆扎法加尔（2.66）和木尔坦（2％）等城市地区则较不普遍。总共150名患者进行了检查，其中88为女性，62名男性，其更频繁地发现病原菌为ë。大肠杆菌（33％）等肺炎克雷伯菌（18％），变形杆菌（10％），腐生葡萄球菌（8.66％），金黄色葡萄球菌（7.33％），铜绿假单胞菌（6.66％），肠杆菌（6％），念珠菌（5.33％）和柠檬酸杆菌（4.66） ％）。对E进行了抗菌药敏试验。表现出亚胺培南（IMI），Cip，Aug，Cfm和CN最高总体耐药性的大肠埃希菌菌株分别为80％，72％，68％，60％和52％。MDR ê。大肠杆菌巴基斯坦对IMI的抗药性最高，这使巴基斯坦的情况令人担忧。重要结果表明，发现TZP，AK和F在体外对E敏感。UTI的大肠杆菌分离株。关于与UTI相关的可能危险因素，本研究首次记录了Multan附近的MDR尿路致病菌的患病率。MDR E的这些令人震惊的迹象。大肠杆菌很少得到解决，需要紧急关注。