The intricate physiology of many Central Nervous System (CNS) disorders points towards oxidative damages of neurons. Various studies have established that oxidative stress is a big threat to integrity of neurons. All the sections of central nervous system are exposed to free radicals and charged species formed during oxidative degradation of catecholamines and polyunsaturated fatty acids which are present abundantly in CNS. By products of other biochemical reactions also contribute to oxidative stress in central nervous system. If these charged species are not counter neutralized by antioxidants, it leads to neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, Amyotropic lateral sclerosis, Multiple sclerosis, Spinal cord injury, Schizophrenia etc. The level of charged species and free radicals is found to be higher in neurodegenerative diseases than normal physiological condition and it is related to oxidative damages to neuronal cells. In many of such cases, use of antioxidants decreases oxidative stress and contribute to neuroprotection. This review intends to compile approach of managing oxidative stress in various neurodegenerative disorders. The perspective of this review is to study antioxidants and their role in neuroprotection.

中文翻译：

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氧化应激引起的神经变性：小分子对神经保护作用的前瞻性综述。

许多中枢神经系统（CNS）疾病的复杂生理学指向神经元的氧化损伤。各种研究已经确定，氧化应激是对神经元完整性的重大威胁。中枢神经系统的所有部分都暴露于在中枢神经系统中大量存在的儿茶酚胺和多不饱和脂肪酸的氧化降解过程中形成的自由基和带电物种。其他生化反应的副产物也有助于中枢神经系统的氧化应激。如果这些带电荷的物种不被抗氧化剂抗中和，则会导致神经退行性疾病，例如阿尔茨海默氏病，帕金森氏病，肌萎缩性侧索硬化症，多发性硬化症，脊髓损伤，精神分裂症等。发现神经退行性疾病中带电物质和自由基的水平高于正常生理条件，并且与神经元细胞的氧化损伤有关。在许多此类情况下，使用抗氧化剂可降低氧化应激并有助于神经保护。这篇综述旨在汇编各种神经退行性疾病中管理氧化应激的方法。本文的目的是研究抗氧化剂及其在神经保护中的作用。