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Therapeutics targeting the fibrinolytic system.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-03-09 , DOI: 10.1038/s12276-020-0397-x Haili Lin 1 , Luning Xu 1 , Shujuan Yu 2 , Wanjin Hong 3 , Mingdong Huang 2 , Peng Xu 3
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-03-09 , DOI: 10.1038/s12276-020-0397-x Haili Lin 1 , Luning Xu 1 , Shujuan Yu 2 , Wanjin Hong 3 , Mingdong Huang 2 , Peng Xu 3
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The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
中文翻译：
针对纤溶系统的治疗药物。
首先确定了纤溶系统的功能以溶解纤维蛋白以维持血管通畅。纤溶系统与许多其他生理和病理过程之间的联系已经建立。纤溶系统的失调与多种病理状况密切相关，包括血栓形成，炎症，癌症进展和神经病。因此，纤溶系统中的分子是有效的治疗和诊断靶标。这篇综述总结了目前针对该系统的药物以及实验研究中新型治疗策略的发展。还讨论了纤溶系统调节剂发展的未来方向。
更新日期：2020-04-24
中文翻译：
针对纤溶系统的治疗药物。
首先确定了纤溶系统的功能以溶解纤维蛋白以维持血管通畅。纤溶系统与许多其他生理和病理过程之间的联系已经建立。纤溶系统的失调与多种病理状况密切相关，包括血栓形成，炎症，癌症进展和神经病。因此，纤溶系统中的分子是有效的治疗和诊断靶标。这篇综述总结了目前针对该系统的药物以及实验研究中新型治疗策略的发展。还讨论了纤溶系统调节剂发展的未来方向。
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