Abstract

The aim of the present study was to evaluate the H₂O₂ scavenging activity of the ZnO₂/β-CD as a biocompatible composite. Zinc peroxide was prepared via sonochemical approach. To synthesize a green composite, β-cyclodextrin was modified by citric acid (CA) and reacted with ZnO₂ under ultrasonic irradiation. The prepared samples were characterized using XRD, SEM, TGA and FTIR analytical techniques. XRD analysis exhibited a typical pattern of ZnO₂ and demonstrated the presence of citric acid and β-cyclodextrin in composite. The results of the catalytic assay showed that the ZnO₂/CA-βCD composite displayed stronger capability to decompose H₂O₂ in comparison to ZnO₂ particles (about seven times). It was attributed to increased adsorption capacity and solubility of composite due to the presence of citric acid and β-cyclodextrin. MTT assay studies confirmed the non-cytotoxic nature of ZnO₂ particles and ZnO₂/CA-βCD composite.

Graphic abstract

中文翻译：

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柠檬酸交联的β-环糊精支持过氧化锌作为生物相容性H2O2清除剂。

摘要

本研究的目的是评估作为生物相容性复合材料的ZnO ₂ /β-CD的H ₂ O ₂清除活性。通过超声化学方法制备过氧化锌。为了合成绿色复合材料，将β-环糊精用柠檬酸（CA）改性，并在超声辐射下与ZnO ₂反应。使用XRD，SEM，TGA和FTIR分析技术对制备的样品进行表征。XRD分析显示出ZnO ₂的典型图案，并证明了复合物中存在柠檬酸和β-环糊精。催化分析结果表明，ZnO ₂ /CA-βCD复合材料具有较强的分解H ₂ O _{2的能力。}与ZnO ₂颗粒相比（约7倍）。这归因于柠檬酸和β-环糊精的存在，提高了复合材料的吸附能力和溶解度。MTT分析研究证实了ZnO ₂颗粒和ZnO ₂ /CA-βCD复合材料的无细胞毒性。

图形摘要