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Citric acid-crosslinked β-cyclodextrin supported zinc peroxide as a biocompatible H2O2 scavenger

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Abstract

The aim of the present study was to evaluate the H2O2 scavenging activity of the ZnO2/β-CD as a biocompatible composite. Zinc peroxide was prepared via sonochemical approach. To synthesize a green composite, β-cyclodextrin was modified by citric acid (CA) and reacted with ZnO2 under ultrasonic irradiation. The prepared samples were characterized using XRD, SEM, TGA and FTIR analytical techniques. XRD analysis exhibited a typical pattern of ZnO2 and demonstrated the presence of citric acid and β-cyclodextrin in composite. The results of the catalytic assay showed that the ZnO2/CA-βCD composite displayed stronger capability to decompose H2O2 in comparison to ZnO2 particles (about seven times). It was attributed to increased adsorption capacity and solubility of composite due to the presence of citric acid and β-cyclodextrin. MTT assay studies confirmed the non-cytotoxic nature of ZnO2 particles and ZnO2/CA-βCD composite.

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Acknowledgements

The authors thank Research Affairs of University of Tabriz for financial support.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, 5166616471, Tabriz, Iran

    Mahtab Pirouzmand & Parya Salahshour Sani

  2. Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, 5166616471, Tabriz, Iran

    Zarrin Ghasemi

  3. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Sajjad Azizi

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  1. Mahtab Pirouzmand
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  2. Parya Salahshour Sani
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  3. Zarrin Ghasemi
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  4. Sajjad Azizi
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Correspondence to Mahtab Pirouzmand.

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Pirouzmand, M., Sani, P.S., Ghasemi, Z. et al. Citric acid-crosslinked β-cyclodextrin supported zinc peroxide as a biocompatible H2O2 scavenger. J Biol Inorg Chem 25, 411–417 (2020). https://doi.org/10.1007/s00775-020-01771-6

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  • DOI: https://doi.org/10.1007/s00775-020-01771-6

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