Studies that investigated neurobiological parameters subtended to impulsivity trait found their relationship with structural and functional brain alterations. No studies investigated the white matter microstructural attributes of impulsivity in a large sample of healthy subjects. In the present study 1007 subjects from Human Connectome Project public dataset were divided in two groups, impulsive and not impulsive, basing on Delay Discounting task score. For both groups brain morphometric and microstructural characteristics were investigated. A t-test (correct for multiple comparisons) was performed for each brain parcel and impulsivity measure. Magnetic resonance diffusion images were pre-processed and selected to perform a voxelwise analysis on the fractional anisotropy (FA) maps between impulsive and not impulsive groups. Group analysis showed significant differences in morphometric brain data mainly for temporal and frontal lobes. The impulsive group presented higher FA values in four regions: bilateral medial lemniscus and midbrain reticular formation, right superior longitudinal fasciculus, left forceps major, right corticospinal tract. Not impulsive group showed higher FA values in two significant regions: right and left anterior thalamus radiation. Concluding, macroscopic and microstructural brain alterations were assessed, identifying new neuroanatomical substrates for multidimensional impulsivity construct in a large sample of healthy subjects.

中文翻译：

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冲动性脑微结构异常：磁共振研究。

研究冲动性格特质的神经生物学参数的研究发现它们与大脑的结构和功能改变有关。没有研究调查大量健康受试者样本中冲动的白质微观结构属性。在本研究中，根据“延迟贴现”任务得分，将来自“人类Connectome项目”公共数据集中的1007名受试者分为冲动型和非冲动型两组。两组均研究了大脑的形态和微观结构特征。对每个大脑包裹和冲动性测验进行了t检验（多次比较均正确）。对磁共振扩散图像进行预处理并选择以对脉冲组和非脉冲组之间的分数各向异性（FA）图进行体素分析。分组分析显示形态学大脑数据的主要差异主要针对颞叶和额叶。冲动组在四个区域表现出较高的FA值：双侧内侧弯月球和中脑网状结构，右上纵筋膜，左大钳，右皮质脊髓束。非冲动组在两个重要区域：右前丘脑和左前丘脑放射显示较高的FA值。最后，对宏观和微观结构的大脑改变进行了评估，从而在大量健康受试者样本中确定了多维冲动构造的新神经解剖学基质。右上纵筋膜，左大钳，右皮质脊髓束。非冲动组在两个重要区域：右前丘脑和左前丘脑放射显示较高的FA值。最后，对宏观和微观结构的大脑改变进行了评估，从而在大量健康受试者样本中确定了多维冲动构造的新神经解剖学基质。右上纵筋膜，左大钳，右皮质脊髓束。非冲动组在两个重要区域：右前丘脑和左前丘脑放射显示较高的FA值。最后，对宏观和微观结构的大脑改变进行了评估，从而在大量健康受试者的样本中确定了多维冲动构造的新神经解剖学基质。