BACKGROUND Rosmarinus officinalis L. is an aromatic perennial herb from which rosmarinic acid (RA) can be extracted. This research was conducted to assess the effectiveness of RA against radio frequency (RF) radiation-induced oxidative stress due to 915 MHz (mobile phone) and 2450 MHz (Wi-Fi) frequencies in rats. METHODS The animals were separated into six groups, including group 1 receiving normal saline (NS), group 2 (NS/Wi-Fi) and group 4 (NS/mobile), which received NS plus 60 min/day of exposure to the electromagnetic radiation (EMR) for 1 month, group 3 (RA/Wi-Fi) and group 5 (RA/mobile) received RA (20 mg/kg/day, po) plus 60 min/day of EMR, and group 6 (RA) received only RA. RESULTS There was a significant elevation of protein carbonylation (PC), nitric oxide (NO) and malondialdehyde (MDA) and significant reduction in glutathione (GSH), glutathione peroxidase (GPx), total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) in the RF radiation-exposed rats' brain compared to the control group. RA reduced the levels of NO, PC and MDA and it also elevated the TAC, GPx, SOD, CAT and GSH levels in the rats' brains in the RA/Wi-Fi and RA/mobile groups compared to the NS/Wi-Fi and NS/mobile groups, respectively. CONCLUSION It can be concluded that RA can be considered a useful candidate for protecting brain tissues against RF radiation-induced oxidative stress at 915 and 2450 MHz frequencies through ameliorative effects on the antioxidant enzyme activities and oxidative stress indices.

中文翻译：

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迷迭香酸对手机和 Wi-Fi 辐射引起的大鼠大脑氧化应激的辐射防护作用。


背景技术迷迭香(Rosmarinus officinalis L.)是一种多年生芳香草本植物，可以从其中提取迷迭香酸(RA)。本研究旨在评估 RA 对大鼠因 915 MHz（手机）和 2450 MHz（Wi-Fi）频率引起的射频 (RF) 辐射引起的氧化应激的有效性。方法将动物分为六组，其中第1组接受生理盐水（NS），第2组（NS/Wi-Fi）和第4组（NS/移动）接受NS加60分钟/天的电磁暴露辐射 (EMR) 1 个月，第 3 组 (RA/Wi-Fi) 和第 5 组（RA/移动）接受 RA（20 毫克/公斤/天，口服）加 60 分钟/天的 EMR，第 6 组（RA ）仅收到 RA。结果 蛋白质羰基化（PC）、一氧化氮（NO）和丙二醛（MDA）显着升高，谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）显着降低与对照组相比，暴露于射频辐射的大鼠大脑中的过氧化氢酶（CAT）。与 NS/Wi-Fi 组相比，RA 降低了 RA/Wi-Fi 组和 RA/mobile 组大鼠大脑中 NO、PC 和 MDA 的水平，并且还升高了 TAC、GPx、SOD、CAT 和 GSH 水平和 NS/移动组。结论 可以得出结论，RA 可以通过改善抗氧化酶活性和氧化应激指数，被认为是保护脑组织免受 915 和 2450 MHz 频率射频辐射诱导的氧化应激的有用候选者。