Alginate oligosaccharides are associated with some beneficial health effects. Gut microbiota is one of the most recently identified factors in the development of several metabolic diseases induced by high-fat diet. Our objective was to evaluate how alginate oligosaccharides impact on high-fat diet‑induced features of metabolic disorders and whether this impact is related to modulations in the modulation of the gut microbiota. C57BL/6J mice were fed with chow diet, high-fat diet, or high-fat diet supplemented with alginate oligosaccharides for 10 weeks. Alginate oligosaccharide treatment improved lipid metabolism, such as reducing levels of TG and LDL-C and inhibiting expression of lipogenesis genes. Alginate oligosaccharide administration reduced the levels of fasting blood glucose and increased the levels of serum insulin. Alginate oligosaccharide treatment was found to lower the expression of markers of inflammation, including IL1β and CD11c. Alginate oligosaccharide treatment modulated gut microbial communities and markedly prompted the growth of Akkermansia muciniphila, Lactobacillus reuteri, and Lactobacillus gasseri. Additionally, alginate oligosaccharide intervention significantly increased concentrations of short-chain fatty acids, such as acetic acid, propionic acid, and butyric acid, as well as decreased levels of endotoxin. Alginate oligosaccharides exert beneficial effects via alleviating metabolic metrics induced by high-fat diet, which is associated with increase in A. muciniphila, L. reuteri, and L. gasseri, as well as the release of microbiota-dependent short-chain fatty acids and inhibition of endotoxin levels.

中文翻译：

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海藻酸低聚糖通过调节高脂饮食喂养小鼠的肠道菌群，改善脂质代谢和炎症。

海藻酸低聚糖与某些有益健康的功效有关。肠道菌群是由高脂饮食诱发的几种代谢疾病发展中的最新发现因素之一。我们的目的是评估藻酸盐寡糖如何影响高脂饮食诱发的代谢紊乱，以及这种影响是否与肠道微生物群调控相关。给C57BL / 6J小鼠喂以低脂饮食，高脂饮食或补充有藻酸盐寡糖的高脂饮食10周。藻酸盐低聚糖处理改善了脂质代谢，例如降低了TG和LDL-C的水平并抑制了脂肪生成基因的表达。藻酸盐低聚糖的施用降低了空腹血糖水平并增加了血清胰岛素水平。发现藻酸盐低聚糖处理降低了炎症标记物的表达，包括IL1β和CD11c。海藻酸钠低聚糖处理可调节肠道微生物群落，并显着促进黏液阿克曼，罗伊氏乳杆菌和加氏乳杆菌的生长。另外，藻酸盐低聚糖干预显着增加了短链脂肪酸（例如乙酸，丙酸和丁酸）的浓度，并降低了内毒素的水平。海藻酸低聚糖通过减轻高脂饮食诱导的代谢指标发挥有益作用，这与粘液曲霉，罗伊氏乳杆菌和加氏乳杆菌的增加以及微生物群相关的短链脂肪酸和抑制内毒素水平。