Fyn is a member of the protein tyrosine kinase family and its overexpression is associated with various types of inflammation. MicroRNAs can regulate the expression of target genes and play an important role in varied physiological and pathological processes. Based on the important role of Fyn and microRNA-125a-3p (miR-125a-3p) in inflammation, and combined with the bioinformatics studies, we performed in this study and chose miR-125a-3p as the focus of our research. During the progression of inflammation, we found that the expression of miR-125a-3p was decreased while the expression of Fyn was up-regulated. Fyn formed a complex with Neuropilin-1, which inhibited odontoblastic differentiation and expanded inflammatory responses through nuclear factor-κB signal pathways in dental pulp stem cells (DPSCs). These findings suggested that miR-125a-3p plays an important role in odontoblastic differentiation of DPSCs by targeting Fyn, implying its therapeutic potential in dental caries.

中文翻译：

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MicroRNA-125a-3p通过靶向Fyn参与牙髓干细胞的成牙本质细胞分化。

Fyn是蛋白酪氨酸激酶家族的成员，其过表达与各种类型的炎症有关。MicroRNA可以调节靶基因的表达，并在各种生理和病理过程中发挥重要作用。基于Fyn和microRNA-125a-3p（miR-125a-3p）在炎症中的重要作用，并结合生物信息学研究，我们在本研究中进行了研究，并选择miR-125a-3p作为我们的研究重点。在发炎过程中，我们发现miR-125a-3p的表达降低而Fyn的表达上调。Fyn与Neuropilin-1形成了复合物，该复合物通过牙髓干细胞（DPSCs）中的核因子-κB信号通路抑制成牙本质细胞分化并扩大炎症反应。