Abstract
Fyn is a member of the protein tyrosine kinase family and its overexpression is associated with various types of inflammation. MicroRNAs can regulate the expression of target genes and play an important role in varied physiological and pathological processes. Based on the important role of Fyn and microRNA-125a-3p (miR-125a-3p) in inflammation, and combined with the bioinformatics studies, we performed in this study and chose miR-125a-3p as the focus of our research. During the progression of inflammation, we found that the expression of miR-125a-3p was decreased while the expression of Fyn was up-regulated. Fyn formed a complex with Neuropilin-1, which inhibited odontoblastic differentiation and expanded inflammatory responses through nuclear factor-κB signal pathways in dental pulp stem cells (DPSCs). These findings suggested that miR-125a-3p plays an important role in odontoblastic differentiation of DPSCs by targeting Fyn, implying its therapeutic potential in dental caries.
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Acknowledgements
The study was partly supported by Graduate Student Innovation of Science and Technology Projects funded by Six Talent Peaks Project in Jiangsu Province (No. 2016-WSN-103), Science and technology Project of Nantong City (MS1201712-2) and Nantong Science and Technology Project (MS22016043).
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Wang, J., Zheng, Y., Bai, B. et al. MicroRNA-125a-3p participates in odontoblastic differentiation of dental pulp stem cells by targeting Fyn. Cytotechnology 72, 69–79 (2020). https://doi.org/10.1007/s10616-019-00358-7
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DOI: https://doi.org/10.1007/s10616-019-00358-7