Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptors (LDLRs) family and accumulating evidence points to the critical role of LRP6 in cardiovascular health and homeostasis. In addition to presenting the well-appreciated roles in canonical signaling regulating blood pressure, blood glucose, lipid metabolism, atherosclerosis, cardiac valve disease, cardiac development, Alzheimer's disease and tumorigenesis, LRP6 also inhibits non-canonical Wnt signals that promote arterial smooth muscle cell proliferation and vascular calcification. Noticeably, the role of LRP6 is displayed in cardiometabolic disease, an increasingly important clinical burden with aging and obesity. The prospect for cardiovascular diseases treatment via targeting LRP6-mediated signaling pathways may improve central blood pressure and lipid metabolism, and reduce neointima formation and myocardial ischemia-reperfusion injury. Thus, a deep and comprehensive understanding of LRP6 structure, function and signaling pathways will contribute to clinical diagnosis, therapy and new drug development for LRP6-related cardiovascular diseases.

中文翻译：

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低密度脂蛋白受体相关蛋白6介导的信号通路和相关的心血管疾病：诊断和治疗机会。

低密度脂蛋白受体相关蛋白6（LRP6）是低密度脂蛋白受体（LDLRs）家族的成员，越来越多的证据表明LRP6在心血管健康和体内平衡中起着关键作用。LRP6除了在调节血压，血糖，脂质代谢，动脉粥样硬化，心脏瓣膜疾病，心脏发育，阿尔茨海默氏病和肿瘤发生的典型信号中发挥公认的作用外，LRP6还抑制非典型Wnt信号，从而促进动脉平滑肌细胞增生和血管钙化。值得注意的是，LRP6在心脏代谢疾病中显示出作用，该疾病在衰老和肥胖中日益重要。通过靶向LRP6介导的信号通路治疗心血管疾病的前景可能会改善中心血压和脂质代谢，并减少新内膜形成和心肌缺血-再灌注损伤。因此，对LRP6的结构，功能和信号通路的深入而全面的了解将有助于LRP6相关性心血管疾病的临床诊断，治疗和新药开发。