Approximately, 1% of human population possesses a copy of human herpesvirus 6A and 6B (HHV-6A/B) in the genome. This viral element is referred to as inherited chromosomally integrated HHV-6A/B (iciHHV-6A/B) and is encoded in all of their cells. A recent study revealed that iciHHV-6A/B potentially increases the immune responses against HHV-6. However, it remains unclear whether iciHHV-6A/B affects human gene expression. Here, we perform global transcriptome analysis using the datasets obtained from various human tissues. We detected two and four individuals positive for iciHHV-6A and iciHHV-6B, respectively, and revealed that the transcriptional expression of iciHHV-6A/B was sporadic in the human body. Transcriptome analysis identified the human genes differentially expressed between iciHHV-6A/B-positive and -negative individuals. Particularly, the expression of some genes encoding immunoglobulins decreased in sigmoid colon of iciHHV-6A/B-positive individuals. Our findings suggest that iciHHV-6A/B may be associated with human health maintenance.

中文翻译：

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继承的染色体整合的HHV-6可能调节人类基因表达。

大约1％的人口在基因组中拥有人类疱疹病毒6A和6B（HHV-6A / B）的副本。该病毒元件被称为遗传整合了染色体的HHV-6A / B（iciHHV-6A / B），并在其所有细胞中编码。最近的一项研究表明，iciHHV-6A / B可能会增强针对HHV-6的免疫反应。但是，尚不清楚iciHHV-6A / B是否影响人类基因表达。在这里，我们使用从各种人体组织获得的数据集进行全局转录组分析。我们分别检测到两个和四个iciHHV-6A和iciHHV-6B阳性的个体，并揭示了iciHHV-6A / B在人体内的转录表达是零星的。转录组分析确定了iciHHV-6A / B阳性和阴性个体之间差异表达的人类基因。尤其，iciHHV-6A / B阳性个体的乙状结肠中一些编码免疫球蛋白的基因的表达下降。我们的发现表明iciHHV-6A / B可能与人类健康维护相关。