The anodized titanium nanotubes (TiO2-NTs) are considered to be a potential material in clinical therapy. To enhance the antibacterial property of TiO2-NTs, cefuroxime is introduced into TiO2-NTs, and then, different chitosan layers are coated to control the release of cefuroxime. SEM and FTIR are adapted for the characterization of prepared TiO2-NTs. The effects of chitosan coating thickness on release of cefuroxime are also investigated, followed with the antibacterial property evaluation. The results show TiO2-NTs are fabricated by anodization method and cefuroxime is also successfully loaded into the nanotubes. The thickness of chitosan coating is an important factor to the release rate of cefuroxime. Antimicrobial detection and morphology observation of S. aureus show a sustained 7-day drug release and strong negative effect on bacteria. The approach in this study provides a broadly applicable method to fabricate titanium-based orthopedic implants with enhanced antibacterial properties.

中文翻译：

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头孢呋辛负载的TiO2纳米管的制备和抗菌性能。

阳极氧化的钛纳米管（TiO2-NTs）被认为是临床治疗中的潜在材料。为了增强TiO2-NTs的抗菌性能，将头孢呋辛引入TiO2-NTs中，然后涂覆不同的壳聚糖层以控制头孢呋辛的释放。SEM和FTIR适用于表征制备的TiO2-NT。还研究了壳聚糖涂层厚度对头孢呋辛释放的影响，并进行了抗菌性能评估。结果表明，通过阳极氧化法制备了TiO2-NTs，并且头孢呋辛也成功地负载到了纳米管中。壳聚糖涂层的厚度是影响头孢呋辛释放速率的重要因素。金黄色葡萄球菌的抗菌检测和形态学观察显示持续7天的药物释放和对细菌的强烈负面影响。