Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Although in recent years there has been a significant progress in the diagnosis, treatment, and prognosis of CVD, but due to their complex pathobiology, developing novel biomarkers and therapeutic interventions are still in need. MicroRNAs (miRNAs) are a fraction of non-coding RNAs that act as micro-regulators of gene expression. Mounting evidences over the last decade confirmed that microRNAs were deregulated in several CVDs and manipulating their expression could affect homeostasis, differentiation, and function of cardiovascular system. Here, we review the current knowledge concerning the roles of miRNAs in cardiovascular diseases with more details on cardiac remodeling, arrhythmias, and atherosclerosis. In addition, we discuss the latest findings on the potential therapeutic applications of miRNAs in cardiovascular diseases.

中文翻译：

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对心血管疾病影响大的小分子。

心血管疾病（CVD）是全球发病率和死亡率的主要原因。尽管近年来在CVD的诊断，治疗和预后方面取得了重大进展，但是由于其复杂的病理生物学特性，仍然需要开发新型的生物标志物和治疗手段。微小RNA（miRNA）是一部分非编码RNA，它们充当基因表达的微调节子。在过去的十年中，越来越多的证据证实，microRNA在几种CVD中被放松调节，操纵其表达可能会影响稳态，心血管系统的分化和功能。在这里，我们回顾了有关miRNA在心血管疾病中作用的最新知识，并详细介绍了心脏重构，心律不齐和动脉粥样硬化。此外，