Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron, Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.

中文翻译：

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TREM2：小胶质细胞中脂质代谢的调节剂。

脱髓鞘过程中的脂质加工机制知之甚少。在本期Neuron 中， Nugent 等人。(2020) 通过细胞特异性脂质组学表明，Trem2缺乏会导致小胶质细胞中的胆固醇酯 (CE) 过载。这是由脂质代谢基因的错误调节介导的，并通过调节 CE 合成或流出来挽救。