Neuron

Neuron

Volume 105, Issue 5, 4 March 2020, Pages 759-761
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TREM2: Modulator of Lipid Metabolism in Microglia

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Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron, Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.

Keywords

microglia
Trem2
ApoE
demyelination
cholesterol transport
neurodegeneration
lipidomics

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