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Development of bioabsorbable zinc-magnesium alloy wire and validation of its application to urinary tract surgeries.
World Journal of Urology ( IF 2.8 ) Pub Date : 2020-02-28 , DOI: 10.1007/s00345-020-03138-7
Yasuyoshi Okamura 1 , Nobuyuki Hinata 1 , Taichi Hoshiba 2 , Tatsuya Nakatsuji 2 , Naoko Ikeo 2 , Junya Furukawa 1 , Kenichi Harada 1 , Yuzo Nakano 1 , Takumi Fukumoto 3 , Toshiji Mukai 2 , Masato Fujisawa 1
Affiliation  

PURPOSE Metallic medical devices are typically constructed from non-bioabsorbable metals that remains in the body and causes considerable complications. Particularly in the urinary tract, calculus, intractable infection, and misdiagnosis as calculus are often caused by non-bioabsorbable metals. Here, we developed a zinc-magnesium alloy as a new bioabsorbable metal and sought to evaluate the bioabsorbable behavior of zinc and zinc-magnesium alloy in a rat bladder implantation model. METHODS We prepared zinc-magnesium alloy wires with various proportions of magnesium and investigated the strength, shape retention, formability, and absorbability of these novel materials. Then, we implanted zinc and zinc-magnesium alloy rings formed by the wires into rat bladder. Rats were euthanized at the end of the observation period, and the rings were removed for volume evaluation. Extracted bladder tissues were subjected to histological analysis. RESULTS The strength of the zinc wire was enhanced by more than fourfold upon the addition of magnesium, without loss of ductility. Linear reduction of ring volume in urine was observed based on the concentration of magnesium within the ring. Nearly all rings were covered with a thin layer of calculus. Histological findings of the transected urinary bladder tissues did not differ among groups. CONCLUSIONS Zinc-magnesium alloy is a promising candidate for use as a bioabsorbable medical device in the urinary tract.

中文翻译:

生物可吸收锌镁合金丝的开发及其在泌尿外科手术中的应用验证。

目的金属医疗器械通常由不可生物吸收的金属制成,这些金属留在体内并引起相当大的并发症。特别是在泌尿道,结石、顽固性感染和误诊为结石往往是由不可生物吸收的金属引起的。在这里,我们开发了一种锌镁合金作为一种新的生物可吸收金属,并试图在大鼠膀胱植入模型中评估锌和锌镁合金的生物可吸收行为。方法我们制备了具有不同镁比例的锌镁合金丝,并研究了这些新型材料的强度、形状保持性、成形性和吸收性。然后,我们将导线形成的锌和锌镁合金环植入大鼠膀胱。在观察期结束时对大鼠实施安乐死,并取下环进行体积评估。提取的膀胱组织进行组织学分析。结果添加镁后,锌线的强度提高了四倍以上,而延展性没有损失。根据环内镁的浓度观察到尿液中环体积的线性减少。几乎所有的戒指都覆盖着一层薄薄的结石。横切膀胱组织的组织学发现在各组之间没有差异。结论 锌镁合金是一种很有前途的候选材料,可用作泌尿道中的生物可吸收医疗器械。根据环内镁的浓度观察到尿液中环体积的线性减少。几乎所有的戒指都覆盖着一层薄薄的结石。横切膀胱组织的组织学发现在各组之间没有差异。结论 锌镁合金是一种很有前途的候选材料,可用作泌尿道中的生物可吸收医疗器械。根据环内镁的浓度观察到尿液中环体积的线性减少。几乎所有的戒指都覆盖着一层薄薄的结石。横切膀胱组织的组织学发现在各组之间没有差异。结论 锌镁合金是一种很有前途的候选材料,可用作泌尿道中的生物可吸收医疗器械。
更新日期:2020-02-28
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