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Development of bioabsorbable zinc–magnesium alloy wire and validation of its application to urinary tract surgeries

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Abstract

Purpose

Metallic medical devices are typically constructed from non-bioabsorbable metals that remains in the body and causes considerable complications. Particularly in the urinary tract, calculus, intractable infection, and misdiagnosis as calculus are often caused by non-bioabsorbable metals. Here, we developed a zinc–magnesium alloy as a new bioabsorbable metal and sought to evaluate the bioabsorbable behavior of zinc and zinc–magnesium alloy in a rat bladder implantation model.

Methods

We prepared zinc–magnesium alloy wires with various proportions of magnesium and investigated the strength, shape retention, formability, and absorbability of these novel materials. Then, we implanted zinc and zinc–magnesium alloy rings formed by the wires into rat bladder. Rats were euthanized at the end of the observation period, and the rings were removed for volume evaluation. Extracted bladder tissues were subjected to histological analysis.

Results

The strength of the zinc wire was enhanced by more than fourfold upon the addition of magnesium, without loss of ductility. Linear reduction of ring volume in urine was observed based on the concentration of magnesium within the ring. Nearly all rings were covered with a thin layer of calculus. Histological findings of the transected urinary bladder tissues did not differ among groups.

Conclusions

Zinc–magnesium alloy is a promising candidate for use as a bioabsorbable medical device in the urinary tract.

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Acknowledgements

The authors are thankful to Institute for Experimental Animals, Kobe University Graduate School of Medicine for breeding rats and providing the necessary laboratory facilities for this work.

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Authors and Affiliations

  1. Department of Urology, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Kobe, Japan

    Yasuyoshi Okamura, Nobuyuki Hinata, Junya Furukawa, Kenichi Harada, Yuzo Nakano & Masato Fujisawa

  2. Department of Mechanical Engineering, Kobe University, Kobe, Japan

    Taichi Hoshiba, Tatsuya Nakatsuji, Naoko Ikeo & Toshiji Mukai

  3. Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Takumi Fukumoto

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  1. Yasuyoshi Okamura
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  2. Nobuyuki Hinata
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Contributions

YO: Data collection, data analysis, manuscript writing; NH: project development, manuscript writing; TH: data collection, data analysis, metal processing; TN: data collection, data analysis, metal processing; NI: project development, data collection, data analysis; JF: data collection; KH: data collection; YN: data collection; TF: project development; TM: project development, manuscript writing; MF: project development.

Corresponding author

Correspondence to Nobuyuki Hinata.

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The authors declare that they have no conflict of interest.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Okamura, Y., Hinata, N., Hoshiba, T. et al. Development of bioabsorbable zinc–magnesium alloy wire and validation of its application to urinary tract surgeries. World J Urol 39, 201–208 (2021). https://doi.org/10.1007/s00345-020-03138-7

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  • DOI: https://doi.org/10.1007/s00345-020-03138-7

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