The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TIGAR expression.

中文翻译：

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TIGAR的动态ROS调节：平衡抗癌和促转移效果。

ROS在癌症中的作用是复杂的，有研究表明其具有促肿瘤作用和抗肿瘤作用。在胰腺导管腺癌模型中，通过TIGAR进行的ROS限制已显示出最初支持癌症的发展，但后来成为转移细胞中的代谢问题，可被TIGAR表达的降低所抵消。