Cancer Cell
Volume 37, Issue 2, 10 February 2020, Pages 141-142
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Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects

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The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TIGAR expression.

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