Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.

中文翻译：

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癌症中分支链氨基酸代谢的新兴作用。

必须调整代谢途径以支持转化和癌症进展所需的细胞过程。在许多癌症中，氨基酸代谢被放松调节，分支链氨基酸代谢的变化特别影响癌细胞的状态以及恶性个体的全身代谢。这篇综述突出了围绕当前对支链氨基酸代谢及其在癌症中的作用的理解的关键概念。