Cancer Cell
Volume 37, Issue 2, 10 February 2020, Pages 147-156
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Review
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

https://doi.org/10.1016/j.ccell.2019.12.011Get rights and content
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Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.

Keywords

branched-chain amino acids
cancer metabolism
metabolism
epigenetics

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