Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.,Journal of Perinatology

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Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41372-020-0614-4
Mihai Puia-Dumitrescu _{1,

2} , Noelle Younge ₂ , Daniel K Benjamin ₃ , Katie Lawson ₄ , Cordelia Hume ₄ , Kennedy Hill ₄ , Jonathan Mengistu ₄ , Aryeona Wilson ₄ , Kanecia O Zimmerman _{2,

4} , Kaashif Ahmad ₅ , Rachel G Greenberg _{2,

4}

Affiliation

OBJECTIVE To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation. STUDY DESIGN Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group. RESULTS This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016). CONCLUSIONS A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.

中文翻译：

妊娠 22-24 周出生婴儿的药物治疗和住院结果。

目的评估妊娠 22-24 周出生婴儿最常用的药物以及院内发病率和死亡率。研究设计对妊娠 22-24 周（2006-2016）出生的婴儿（2006-2016 年）进行的多中心回顾性队列研究，这些婴儿没有重大先天异常，并使用从 Pediatrix 医疗集团管理的新生儿重症监护病房获得的可用药物数据。结果这项研究包括来自 195 个地点的 7578 名婴儿。中位数（第 25、75 个百分位数）：出生体重为 610 克（540、680）；使用的不同药物数量为 13 种 (8, 18)；不同抗菌药物暴露量为 4 (2, 5)。最常见的发病是 BPD (41%) 和 III 级或 IV 级 IVH (20%)，总生存率从 46% (2006) 到 57% (2016) 不等。结论围产儿使用了大量药物。院内发病率很高，并且该人群的存活率在研究期间有所增加。

更新日期：2020-02-18

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