Under continuous processing conditions, C-N bond formation via SN₂ and SNAr substitutions by amines can be an effective preparative method, especially when volatile amines are used under high pressure and temperature. We have demonstrated SN₂ substitution of a 2° mesylate with ammonia and opening of an epoxide with benzylamine, and SNAr substitution of a heteroaryl chloride with aqueous ammonia on multi-kg scales. The homogeneous continuous processes offered better process control, higher efficiency, and comparable or superior reaction profiles and yields to batch conditions.

Continuous flow aminolysis under high temperature and pressure

中文翻译：

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高温高压连续流氨解

在连续加工条件下，通过SN ₂形成CN键和用胺取代SNAr可能是一种有效的制备方法，尤其是在高压和高温下使用挥发性胺时。我们已经证明了用氨水将2°甲磺酸盐进行SN ₂取代，并用苄胺打开了环氧化物，以及用氨水将杂芳基氯的SNAr取代了几千克规模。均匀的连续过程可提供更好的过程控制，更高的效率，以及可与批处理条件相比或更高的反应曲线和产率。

高温高压连续流氨解