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Long noncoding RNAs as novel players in the pathogenesis of hypertension
Hypertension Research ( IF 4.3 ) Pub Date : 2020-02-05 , DOI: 10.1038/s41440-020-0408-2 Xiaoying Jiang 1 , Qilan Ning 1
Hypertension Research ( IF 4.3 ) Pub Date : 2020-02-05 , DOI: 10.1038/s41440-020-0408-2 Xiaoying Jiang 1 , Qilan Ning 1
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Long noncoding RNAs (lncRNAs) are non-(protein)-coding RNAs longer than ~200 nucleotides and have been reported to be involved in multiple human diseases by regulating gene expression. A growing body of evidence has demonstrated that lncRNAs are also widely implicated in mechanisms of hypertension, including regulation of the proliferation, migration, and apoptosis of VSMCs; the production of iNOS and NO; and the angiogenic function of endothelial cells. Several lncRNAs were also differentially expressed in the renal and cardiac tissues of hypertensive rats and even in placental samples from preeclampsia patients. In particular, several circulating lncRNAs have been identified as novel biomarkers of hypertension. In this review, we summarize the current studies of lncRNAs in the pathogenesis of hypertension in order to aid in better understanding the molecular mechanism of hypertension and provide a basis to explore new therapeutic targets.
中文翻译：
长链非编码 RNA 作为高血压发病机制的新参与者
长链非编码 RNA (lncRNA) 是长度超过约 200 个核苷酸的非（蛋白质）编码 RNA，据报道通过调节基因表达参与多种人类疾病。越来越多的证据表明，lncRNA 也广泛参与高血压机制，包括调节 VSMC 的增殖、迁移和凋亡；iNOS 和 NO 的产生；以及内皮细胞的血管生成功能。在高血压大鼠的肾脏和心脏组织中，甚至在先兆子痫患者的胎盘样本中，几种 lncRNA 也有差异表达。特别是，几种循环 lncRNA 已被鉴定为高血压的新型生物标志物。在这次审查中，
更新日期：2020-02-05
中文翻译：
长链非编码 RNA 作为高血压发病机制的新参与者
长链非编码 RNA (lncRNA) 是长度超过约 200 个核苷酸的非（蛋白质）编码 RNA，据报道通过调节基因表达参与多种人类疾病。越来越多的证据表明，lncRNA 也广泛参与高血压机制，包括调节 VSMC 的增殖、迁移和凋亡；iNOS 和 NO 的产生；以及内皮细胞的血管生成功能。在高血压大鼠的肾脏和心脏组织中，甚至在先兆子痫患者的胎盘样本中，几种 lncRNA 也有差异表达。特别是，几种循环 lncRNA 已被鉴定为高血压的新型生物标志物。在这次审查中，
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