Abstract—

This paper describes the stages of osteogenic differentiation of chondrogenic graft in a culture medium and recipient bed (defect of bone tissue). In the culture medium, cell and matrix transformations, formation of vascular cavities with an endothelial lining and matrix vesicles in osteoblasts (the first stage of mineralization) take place in the chondrograft. The expression of chondrogenic genes and proteins is replaced by the expression of genes and proteins of the osteogenic stage of differentiation. Further stages of bone tissue histogenesis occur in the recipient bed. Humoral factors of regulation and ductile substance enter through the formed anastomosis of the vessels of osteodysplastica and recipient. On their basis, the formation of an organ-specific regenerate is completed with full integration into the recipient organism. These results are a starting point for further use of osteogenic grafts in clinical practice.

中文翻译：

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培养基和受体床中成骨移植物的组织发生阶段

摘要—

本文介绍了在培养基和受体床（骨组织缺损）中成软骨移植物的成骨分化阶段。在培养基中，成软骨细胞（成矿的第一阶段）中发生了细胞和基质的转化，形成了带有内皮层和基质囊泡的血管腔（软骨形成的第一阶段）。软骨形成基因和蛋白质的表达被成骨分化阶段的基因和蛋白质的表达所取代。骨组织组织发生的其他阶段发生在受体床上。体液调节和延性物质的体液因素通过骨发育不良和受体血管形成的吻合进入。在它们的基础上，器官特异性再生物的形成与受体生物完全整合。