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Porous conductive and biocompatible scaffolds on the basis of polycaprolactone and polythiophene for scaffolding
Polymer Bulletin ( IF 3.1 ) Pub Date : 2019-06-08 , DOI: 10.1007/s00289-019-02732-z
Raana Sarvari , Bakhshali Massoumi , Amir Zareh , Younes Beygi-Khosrowshahi , Samira Agbolaghi

The fabrication of novel scaffolds was represented on the basis of conductive and biodegradable copolymers. The star-like polycaprolactone (S-PCL) was synthesized from dipentaerythritol as a core by a catalyst of Sn(oct) 8 through ring-opening technique. After functionalization of S-PCL by thiophene, thiophene monomer was polymerized from polycaprolactone ends via chemical oxidation polymerization to reach star-like polycaprolactone–polythiophene (S-PCL–PTh). The scaffolds demonstrated a porous configuration (160–190 nm) having the great surface area as well as conductivity of 0.011 S cm −1 . The cytocompatibility measurements exhibited that the nanofibers were not toxic to the MG63 cells.

中文翻译:

基于聚己内酯和聚噻吩的多孔导电和生物相容性支架用于支架

新型支架的制造以导电和可生物降解的共聚物为基础。以二季戊四醇为核心,以Sn(oct) 8 为催化剂,通过开环技术合成了星状聚己内酯(S-PCL)。S-PCL 被噻吩官能化后,噻吩单体从聚己内酯末端通过化学氧化聚合得到星状聚己内酯-聚噻吩(S-PCL-PTh)。支架表现出多孔结构(160-190 nm),具有很大的表面积以及0.011 S cm -1 的电导率。细胞相容性测量表明纳米纤维对 MG63 细胞没有毒性。
更新日期:2019-06-08
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