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Porous conductive and biocompatible scaffolds on the basis of polycaprolactone and polythiophene for scaffolding

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Abstract

The fabrication of novel scaffolds was represented on the basis of conductive and biodegradable copolymers. The star-like polycaprolactone (S-PCL) was synthesized from dipentaerythritol as a core by a catalyst of Sn(oct)8 through ring-opening technique. After functionalization of S-PCL by thiophene, thiophene monomer was polymerized from polycaprolactone ends via chemical oxidation polymerization to reach star-like polycaprolactone–polythiophene (S-PCL–PTh). The scaffolds demonstrated a porous configuration (160–190 nm) having the great surface area as well as conductivity of 0.011 S cm−1. The cytocompatibility measurements exhibited that the nanofibers were not toxic to the MG63 cells.

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Authors and Affiliations

  1. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran

    Raana Sarvari

  2. Department of Chemistry, Payame Noor University, P.O. BOX 19395-3697, Tehran, Islamic Republic of Iran

    Bakhshali Massoumi & Amir Zareh

  3. Chemical Engineering Department, Faculty of Engineering, Azarbaijan Shahid Madani University, P.O. BOX 5375171379, Tabriz, Islamic Republic of Iran

    Younes Beygi-Khosrowshahi & Samira Agbolaghi

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  1. Raana Sarvari
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  2. Bakhshali Massoumi
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  3. Amir Zareh
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  4. Younes Beygi-Khosrowshahi
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  5. Samira Agbolaghi
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Sarvari, R., Massoumi, B., Zareh, A. et al. Porous conductive and biocompatible scaffolds on the basis of polycaprolactone and polythiophene for scaffolding. Polym. Bull. 77, 1829–1846 (2020). https://doi.org/10.1007/s00289-019-02732-z

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  • DOI: https://doi.org/10.1007/s00289-019-02732-z

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