Amines are invaluable precursors and necessary chemical components in industrial settings as well as pharmaceutical industries, making methods for efficient formation of C-N bonds a vital chemical process. Of these methods, the hydroamination of alkenes and alkynes, specifically the addition of an N-H bond across a carbon-carbon π-bond, is especially relevant. The hydroamination reaction is theoretically 100% atom-economical, making it a desirable synthetic route for the formation of C-N bonds. Common synthetic methods for amines are cumbersome and require multiple steps that produce waste products. However, the hydroamination reaction itself has a large negative entropy, requiring the assistance of a catalyst to promote the reaction. As such, current research focuses on the development of organometallic catalysts that can increase the efficacy of hydroamination reactions. Herein, research towards the development of an efficient catalyst for intramolecular hydroamination of alkene is reviewed.

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烯烃分子内加氢胺化的有机金属催化剂

胺是工业环境和制药工业中不可估量的前体和必要的化学成分，这使得有效形成CN键的方法成为至关重要的化学过程。在这些方法中，烯烃和炔烃的加氢胺化，特别是在碳-碳π键上加成NH键特别重要。理论上，加氢胺化反应是100％原子经济的，这使其成为形成CN键的理想合成途径。胺的常规合成方法麻烦，并且需要产生废物的多个步骤。然而，氢化胺化反应本身具有较大的负熵，需要催化剂的辅助来促进反应。因此，目前的研究集中在有机金属催化剂的开发上，该催化剂可以提高加氢胺化反应的效率。本文中，综述了对开发用于烯烃的分子内加氢胺化的有效催化剂的研究。