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Organometallic catalysts for intramolecular hydroamination of alkenes

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Abstract

Amines are invaluable precursors and necessary chemical components in industrial settings as well as pharmaceutical industries, making methods for efficient formation of C-N bonds a vital chemical process. Of these methods, the hydroamination of alkenes and alkynes, specifically the addition of an N-H bond across a carbon-carbon π-bond, is especially relevant. The hydroamination reaction is theoretically 100% atom-economical, making it a desirable synthetic route for the formation of C-N bonds. Common synthetic methods for amines are cumbersome and require multiple steps that produce waste products. However, the hydroamination reaction itself has a large negative entropy, requiring the assistance of a catalyst to promote the reaction. As such, current research focuses on the development of organometallic catalysts that can increase the efficacy of hydroamination reactions. Herein, research towards the development of an efficient catalyst for intramolecular hydroamination of alkene is reviewed.

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  1. Department of Chemistry and Biochemistry, Gonzaga University, 502 E. Boone Ave, Spokane, WA, 99203, USA

    Duncan A. Patton & Matthew E. Cremeens

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  1. Duncan A. Patton
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  2. Matthew E. Cremeens
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Correspondence to Duncan A. Patton.

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Patton, D.A., Cremeens, M.E. Organometallic catalysts for intramolecular hydroamination of alkenes. Ref. J. Chem. 4, 1–20 (2014). https://doi.org/10.1134/S207997801304002X

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