PURPOSE To investigate brain morphological alterations of high-tension glaucoma patients and explore the association between brain morphological changes and elevated intraocular pressure. METHODS Thirty-six patients with high-tension glaucoma and 20 healthy controls were collected and underwent structural MRI scan. Surface-based morphometry and voxel-based morphometry were applied to assess cortical thickness and subcortical gray matter volume of the enrolled subjects. The association between brain morphometry and intraocular pressure was assessed by partial correlation. RESULTS Compared with healthy controls, high-tension glaucoma patients showed decreased cortical thickness in the bilateral superior temporal gyrus, bilateral superior parietal gyrus, bilateral lateral occipital gyrus, left fusiform gyrus, left medial orbitofrontal gyrus, right precentral gyrus, and right superior frontal gyrus (p < 0.05). High-tension glaucoma patients also showed reduced gray matter volume in the right hippocampus, bilateral putamen, and bilateral thalamus (p < 0.05). In addition, brain morphological correlates of mean intraocular pressure were found in the left rostral middle frontal gyrus, right precentral gyrus, and left postcentral gyrus in high-tension glaucoma group (p < 0.05). CONCLUSION High-tension glaucoma patients experienced morphological reduction in the visual and nonvisual areas throughout the entire brain. Elevated intraocular pressure may contribute to the reduction of cortical thickness in certain areas in the progression of the disease.

中文翻译：

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高压青光眼脑的大脑皮质和皮层下核的形态变化及其与眼压的关系。

目的探讨高血压青光眼患者的脑形态变化，探讨脑形态变化与眼压升高之间的关系。方法收集36例高血压青光眼患者和20例健康对照者，并进行结构MRI扫描。基于表面的形态学和基于体素的形态学被用于评估入选受试者的皮质厚度和皮质下灰质体积。通过部分相关性评估脑形态计量学与眼内压之间的关联。结果与健康对照组相比，高血压青光眼患者的双侧颞上回，双侧顶顶回，双侧枕侧回，左梭状回，左眶额前回的皮层厚度减少，右前中央回和右上额回（p <0.05）。高血压青光眼患者的右海马，双侧壳核和双侧丘脑灰质体积也减少（p <0.05）。此外，在高压青光眼组中，左眼中额回，右中前回和左中后回均发现了平均眼压的脑形态学相关性（p <0.05）。结论高血压青光眼患者的整个大脑的视觉和非视觉区域均发生形态学降低。眼内压升高可能会导致疾病进展过程中某些区域的皮质厚度减少。高血压青光眼患者的右海马，双侧壳核和双侧丘脑灰质体积也减少（p <0.05）。此外，在高压青光眼组中，左眼中额回，右中前回和左中后回均发现了平均眼压的脑形态学相关性（p <0.05）。结论高血压青光眼患者的整个大脑的视觉和非视觉区域均发生形态学降低。眼内压升高可能有助于疾病进展过程中某些区域的皮质厚度减少。高血压青光眼患者的右海马，双侧壳核和双侧丘脑灰质体积也减少（p <0.05）。此外，在高压青光眼组中，左眼中额回，右中前回和左中后回均发现了平均眼压的脑形态学相关性（p <0.05）。结论高血压青光眼患者的整个大脑的视觉和非视觉区域均发生形态学降低。眼内压升高可能会导致疾病进展过程中某些区域的皮质厚度减少。高压青光眼组左眼中额额回，右中前回和左中后回的平均眼压与脑形态相关（p <0.05）。结论高血压青光眼患者的整个大脑的视觉和非视觉区域均发生形态学降低。眼内压升高可能会导致疾病进展过程中某些区域的皮质厚度减少。高压青光眼组左眼中额额回，右中前回和左中后回的平均眼压与脑形态相关（p <0.05）。结论高血压青光眼患者的整个大脑的视觉和非视觉区域均发生形态学降低。眼内压升高可能会导致疾病进展过程中某些区域的皮质厚度减少。