Abstract

Osteosarcopenia is an increasingly recognized geriatric syndrome with a considerable prevalence which increases morbidity and mortality. Although osteosarcopenia is a result of age-related deterioration in muscle and bone, there are many risk factors that provoking osteosarcopenia. These risk factors should be considered by the clinicians to treat osteosarcopenia. We assessed the link between osteosarcopenia and conventional risk factors of cardiovascular diseases. This study was a cross-sectional study that has been conducted within the framework of Bushehr Elderly Health (BEH) program stage II in which participants aged ≥ 60 years were included. Osteopenia/osteoporosis was defined as a t-score ≤ − 1.0 standard deviation below the mean values of a young healthy adult. We defined sarcopenia as reduced skeletal muscle mass plus low muscle strength and/or low physical performance. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We estimated the age-standardized prevalence of osteosarcopenia for men and women, separately. Using modified Poisson regression analysis, adjusted prevalence ratio (PR) with 95% CI was used to show the measure of associations in the final model. Among 2353 participants, 1205 (51.2%) were women. Age-standardized prevalence of osteosarcopenia was 33.8 (95% CI 31.0–36.5) in men and 33.9 (30.9–36.8) in women. In both sexes, the inverse association was detected with body mass index and having osteosarcopenia (PR 0.84, 95% CI 0.81–0.88 in men and 0.77, 95% CI 0.74–0.80 in women). In both sexes, high-fat mass was positively associated with osteosarcopenia [PR 1.46 (95% CI 1.11–1.92) in men, and 2.25 (95% CI 1.71–2.95) in women]. Physical activity had a significant inverse association in men (PR = 0.64, 95% CI 0.46, 0.88), but not in women. Diabetes was also showed a direct association with osteosarcopenia in men (PR 1.33, 95% CI 1.04–1.69). No associations were detected between the lipid profiles and osteosarcopenia. Results demonstrated a high prevalence of osteosarcopenia in both sexes suggesting a high disease burden in a rapidly aging country. Lifestyle and socioeconomic factors, as well as chronic diseases, were significantly associated with osteosarcopenia.

中文翻译：

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伊朗老年人骨软骨减少症的患病率及其与心血管危险因素的关系：布什尔老人健康（BEH）计划。

摘要

骨骨减少症是一种越来越多的公认的老年综合症，其患病率很高，会增加发病率和死亡率。尽管骨少肌症是与年龄相关的肌肉和骨骼退化的结果，但有许多诱发骨少肌症的危险因素。临床医师应考虑这些危险因素以治疗骨质减少症。我们评估了骨减少症与心血管疾病的常规危险因素之间的联系。这项研究是一项横断面研究，已在布什尔老年健康（BEH）计划第二阶段的框架内进行，其中包括年龄≥60岁的参与者。骨质减少/骨质疏松症定义为t-分数≤-1.0标准差，低于年轻健康成年人的平均值。我们将肌肉减少症定义为骨骼肌质量降低加上肌肉力量低和/或身体机能低下。骨质减少症被认为是同时存在骨质减少/骨质疏松和肌肉减少症。我们分别估算了男女年龄骨化症的年龄标准化患病率。使用改进的泊松回归分析，使用具有95％CI的调整患病率（PR）来显示最终模型中的关联度。在2353位参与者中，有1205位（51.2％）是女性。男性的年龄标准化骨质减少症患病率为33.8（95％CI 31.0–36.5），女性为33.9（30.9–36.8）。在男女中，都与体重指数和骨质疏松症呈负相关（男性PR 0.84，95％CI 0.81-0.88，0.77，95％CI 0.74-0。女性80岁）。在男性和女性中，高脂脂肪与骨质疏松症呈正相关[男性PR 1.46（95％CI 1.11–1.92），女性2.25（95％CI 1.71–2.95）。男性的体育活动具有显着的负相关性（PR = 0.64，95％CI 0.46，0.88），而女性则没有。糖尿病也显示与男性骨少症直接相关（PR 1.33，95％CI 1.04–1.69）。在脂质分布和骨少症之间未发现关联。结果表明，男女骨质疏松症的患病率很高，表明在一个快速老龄化的国家中疾病负担很高。生活方式和社会经济因素以及慢性疾病与骨少症显着相关。95）]。男性的体育活动具有显着的负相关性（PR = 0.64，95％CI 0.46，0.88），而女性则没有。糖尿病也显示与男性骨少症直接相关（PR 1.33，95％CI 1.04–1.69）。在脂质分布和骨少症之间未发现关联。结果表明，男女骨质疏松症的患病率很高，表明在一个快速老龄化的国家中疾病负担很高。生活方式和社会经济因素以及慢性疾病与骨少症显着相关。95）]。男性的体育活动具有显着的负相关性（PR = 0.64，95％CI 0.46，0.88），而女性则没有。糖尿病也显示与男性骨少症直接相关（PR 1.33，95％CI 1.04–1.69）。在脂质分布和骨少症之间未发现关联。结果表明，男女骨质疏松症的患病率很高，表明在一个快速老龄化的国家中疾病负担很高。生活方式和社会经济因素以及慢性疾病与骨少症显着相关。在脂质分布和骨少症之间未发现关联。结果表明，男女骨质疏松症的患病率很高，表明在一个快速老龄化的国家中疾病负担很高。生活方式和社会经济因素以及慢性疾病与骨少症显着相关。在脂质分布和骨少症之间未发现关联。结果表明，男女骨质疏松症的患病率很高，表明在一个迅速老龄化的国家中疾病负担很高。生活方式和社会经济因素以及慢性疾病与骨少症显着相关。